Institute of Physical Biology
Velika Loka 90
SI - 1290 Grosuplje
tel/fax: +386 1 7863682
Dr. Alexis Zrimec
The Institute of Physical Biology is a non-profit private research
organisation in the field of physical biology (=biophysics). We are a RTD
project-oriented organisation, but also with educational (workshops,
publishing) goals. Our expertise is understanding biological processes from
a physical and mathematical perspective, process analysis based on
fundamental understanding of molecular biology, physiology, physics and
mathematics, interpretation and model simulations. We gather researchers
from the fields of biophysics, animal and plant physiology, mathematics,
physics, ecotoxicology, and others.
We designed a system for measuring weak photon emission from
We applied the system for measuring delayed fluorescence of algae
and higher plants in order to detect stress and measure some parameters of
photosynthesis. We have used the system to test the effects of
environmental exposure to complex chemical mixtures, especially heavy
metals and herbicides, and could be used as an alternative to animal
testing. The method could also be used as a high throughput analysis of
plant metabolism. Luminescence measurements from plants are also correlated
to viral infections due to the elevated reactive oxygen species
concentrations in infected plants - we are using the system to measure the
infection event of potato plants.
We perform delayed fluorescence and fluorescence measurements
of marine algae to set up a system for monitoring the toxic algal
populations and algal blooms in connection with aquaculture and turism.
Weak photon emission from human cells can be used as an
non-invasive diagnostic technique for early cancer detection, any other
stress to the nuclear DNA, and tumor imaging. We are currently
investigating this phenomenon.
Biophysics, Physical Biology
Delayed fluorescence, Delayed luminescence
Alternatives to animal testing
Non-invasive cancer diagnostics
RTD in biology, biophysics, microelectronics for
physiology, non-invasive medical diagnostics, or ecotoxicology. Partners
for joint RTD and end-users for our RTD.
Website is under construction...